Assessment of Effects of Phlebotomy in Patients with Polycythemia Vera and Secondary Polycythemia / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 265-274, 2013.
Article
em Ko
| WPRIM
| ID: wpr-40700
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Polycythemia vera (PV) is a myeloproliferative neoplasm that can cause complications such as thrombosis and organ damage. To prevent complications of PV, therapy for maintenance of a hematocrit target of less than 45% has been recommended and phlebotomy is a simple therapy. However, the effects of phlebotomy have not been well evaluated in Korea. Therefore, we evaluated the effects of phlebotomy performed in patients with PV and secondary polycythemia.METHODS:
The clinical data and phlebotomy records of 15 patients diagnosed with PV and secondary polycythemia from May 2005 to March 2013 at the National Cancer Center were reviewed retrospectively.RESULTS:
Patients included 10 males and five females. The median age of patients was 63 years (range, 50~72 years). There were six PV patients (40%) and nine secondary polycythemia patients (60%). The mean number of phlebotomy attempts per patient was 6 (range, 1~22), with an interval between phlebotomy attempts of 16 weeks (range, 1~96 weeks). The mean phlebotomy volume was 458 mL, which was 10.3% of the total blood volume. After phlebotomy, the mean hematocrit showed a decline, from 50.4 (+/-4.35)% to 46.5 (+/-4.85)%, and symptoms improved. After phlebotomies, 10 patients achieved a hematocrit of less than 45% and this hematocrit level was obtained after an average of six phlebotomies.CONCLUSION:
Phlebotomy is an effective treatment modality for lowering the hematocrit value in patients with PV and secondary polycythemia. However, target hematocrit was not achieved after a single phlebotomy. Therefore, adjustment of visit intervals and changes in phlebotomy volume were needed.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Policitemia
/
Policitemia Vera
/
Trombose
/
Volume Sanguíneo
/
Estudos Retrospectivos
/
Flebotomia
/
Hematócrito
/
Coreia (Geográfico)
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Blood Transfusion
Ano de publicação:
2013
Tipo de documento:
Article