Effects of the indoleamine 2,3- dioxygenase- initiated L- tryptophan metabolism in organ transplantation / 国际外科学杂志
International Journal of Surgery
; (12): 339-342, 2012.
Article
em Zh
| WPRIM
| ID: wpr-418773
Biblioteca responsável:
WPRO
ABSTRACT
Tryptophan is the essential amino acid in the growth of cell.Indoleamine 2,3-dioxygenase is the rate-limiting enzyme in the catabolism of tryptophan along the kynurenine pathway.Indoleamine 2,3-dioxygenase enzyme mainly promotes tryptophan consumption of local micro-environment,causing tryptophan lack,thus inhibiting proliferation and activation of T cell.Tryptophan-derived catabolites suppress allogeneic T-cell proliferation (kynurenine,3-hydroxykynurenine,and 3-hydroxyanthranilate).Indoleamine 2,3-dioxygenase dendritic cells may interact with regulatory T cells forming an immunomodulatory network to promote immune tolerance induction.Though the immune regulation mechanism of the indoleamine 2,3-dioxygenase-initiated L-tryptophan in transplantation remains unclear,Numerous researches indicate that its role of tolerance induction in transplantation will be significant.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
International Journal of Surgery
Ano de publicação:
2012
Tipo de documento:
Article