Effects of Alprostadil combined with Enalapril on high sensitivity C-reactive protein and cystatin in patients with early diabetic nephropathy / 中国综合临床
Clinical Medicine of China
; (12): 1062-1065, 2011.
Article
em Zh
| WPRIM
| ID: wpr-422719
Biblioteca responsável:
WPRO
ABSTRACT
Objective To evaluate the effects of Alprostadil combined with Enalapril on high sensitivity C-reactive protein and Cystatin in patients with early diabetic nephropathy.Methods One hundred and fifteen cases of outpatients were randomized into 3 groups.Thirty-seven cases were assigned to Alprostadil group and treated with Alprostadil 10 μg + NS 100 ml,iv,qid;Thirty-eight cases were assigned to the Analapril group and treated with Enalapril 5 mg bid;Forty cases were assigned to the combined treatment group and treated with Alprostadil 10 μg + NS 100 ml,iv qid and Enalapril 5mg bid.All patients were observed for twelve weeks.Changes before and after treatment in the blood pressure,plasma glucose,glycolated hemoglobin (HbA1 c),24 hours urinary albumin (24 hUAE),high-sensitive C-reactive protein(hs-CRP) and Cystain C( Cys C) were observed and compared between the three groups.Results After treatment,hs-CRP,CysC and 24 h UAE were significantly improved in the three groups compared with baseline levels( P < 0.05).In the combined treatment group,hs-CRP,CysC and 24 h UAER had a more significant improvement than the other two groups (P <0,05 ).Conclusion Alprostadil combined with Enalapril is a clinically effective strategy in the treatment of early diabetic nephropathv and can reduce the levels of CysC and hs-CRP.
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Base de dados:
WPRIM
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Idioma:
Zh
Revista:
Clinical Medicine of China
Ano de publicação:
2011
Tipo de documento:
Article