Expression and clinical significance of hepatocyte growth factor receptor and epidermal growth factor receptor in pancreatic cancer / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 447-451, 2012.
Article
em Zh
| WPRIM
| ID: wpr-426587
Biblioteca responsável:
WPRO
ABSTRACT
Objective To determine the clinical significance of hepatocyte growth factor receptor (Met) and epidermal growth factor receptor (EGFR) in the clinicopathology and prognosis of pancreatic cancer.Methods 70 patients admitted with pancreatic cancer from 1995 to 2005 were retrospectively analyzed with clinicopathological and follow-up data.Expression of Met and EGFR in cancer nest embedded with paraffin were detected by immunohislostaining (EnVision method) and correlation with clinicopathologic parameters and mutual correlation between these two receptors were further analyzed.Prognosis and related risk factors were analyzed by Kaplan-Meier survival analysis and Cox regression analysis,respectively.Results Both Met and EGFR significantly correlated with TNM staging,tumor size and superior mesenteric vessels invasion (P<0.05).Expression level of Met positively correlated with that of EGFR (r9 =0.658,P<0.05).Both Met and EGFR significantly correlated with patients' survival (P<0.05) and Met was an independent prognostic risk factor for pancreatic cancer.Conclusions Both Met and EGFR significantly affect development and prognosis of pancreatic cancer and correlate with each other.Simultaneously targeting both Met and EGFR pathways may provide an advisable strategy of targeted therapy in pancreatic cancer.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
Chinese Journal of Hepatobiliary Surgery
Ano de publicação:
2012
Tipo de documento:
Article