DETECTION OF THE LEVELS OF THE IFN-γ AND TNF-α IN SERUM OF THE PATIENES WITH THE DENGUE VIRUS INFECTION AND ITS CLINICAL SIGNIFICANCE / 中国人兽共患病学报
Chinese Journal of Zoonoses
; (12): 19-21, 2001.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-433865
Biblioteca responsável:
WPRO
ABSTRACT
AimTo study the effect of interferon gamma( IFN-γ) and tumor necrosis factor alpha(TNF-α) in the immune pathogenesis of dengue virus infection. Method The serum levels of IFN-γ and TNF-α were measured with emzyme linked immunosorbent assay (ELISA) method in 30 cases of the patients with the dengue virus infection in Guangzhou district. The results were treated with t-test of two sample mean. ResultsThe serum levels of IFN-γ and TNF-α in patients with the dengue virus infection were much higher than healthy controls( P < 0.05、 P < 0.01 ). IFN-γ was detectable on the first day of postinfection. Level of IFN-γ reached their peaks on the second day, then declined . The level of TNF-α had an obvious rise from the second day and reached their peaks on the third day, then declined. ConclusionThe data suggest that the IFN-γ and TNF-α may play an important role in the dengue virus pathogenicity and immunity.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Dengue
/
Doenças Negligenciadas
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Chinese Journal of Zoonoses
Ano de publicação:
2001
Tipo de documento:
Artigo