Effect of Proton Pump Inhibitor in Patients with Acute Pancreatitis: Pilot Study / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 362-367, 2012.
Article
em Ko
| WPRIM
| ID: wpr-43466
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Oxygen free radicals play an important role in acute pancreatitis. Pantoprazole as a proton pump inhibitor (PPI) has pancreatic anti-secretory effect and a pronounced inhibitory reactivity towards hydroxyl radicals. The objective of the study was to investigate the effect of pantoprazole on the course of acute pancreatitis.METHODS:
We conducted a prospective randomized trial involving 40 patients with acute pancreatitis. Patients were divided into two groups. One group received PPI and the other group did not receive PPI. In the PPI group, patients received pantoprazole 40 mg intravenously twice a day for fasting time, and then 40 mg orally twice a day until discharge.RESULTS:
There were no significant differences in baseline characteristics and laboratory markers between two groups. In the pantoprazole group, mean hospital stay was 7.4 days, time to start oral intake was 69.0 hours, and time to pain relief was 59.7 hours. Acute physiology and chronic health evaluation (APACHE) II score was 3.15 at admission day and 2.35 at discharge. On the other hand, in the non-pantoprazole group, mean hospital stay was 7.6 days, time taken to start oral intake was 71.4 hours, and time taken to pain relief was 61.8 hours. APACHE II score was 4.4 at admission and 2.85 at discharge. However, there were no significant differences between two groups.CONCLUSIONS:
Treatment with pantoprazole did not have influence on the clinical course of acute pancreatitis. But, considering it was a pilot study, large scale prospective trials will be needed.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pancreatite
/
Consumo de Bebidas Alcoólicas
/
Projetos Piloto
/
Doença Aguda
/
Estudos Prospectivos
/
APACHE
/
Ingestão de Alimentos
/
2-Piridinilmetilsulfinilbenzimidazóis
/
Inibidores da Bomba de Prótons
/
Manejo da Dor
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
Ko
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2012
Tipo de documento:
Article