Association of the Catechol-o-Methyltransferase Gene Polymorphisms with Korean Autism Spectrum Disorders
Journal of Korean Medical Science
; : 1403-1406, 2013.
Article
em En
| WPRIM
| ID: wpr-44040
Biblioteca responsável:
WPRO
ABSTRACT
This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, P(FDR) = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated significant evidence of an association with ASDs (additive model rs6269-rs4818-rs4680-rs769224 haplotype P = 0.004, P(FDR) = 0.040). Thus, an association may exist between the variants of the COMT gene and the occurrence of ASDs in Koreans.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Haplótipos
/
Catecol O-Metiltransferase
/
Desequilíbrio de Ligação
/
Transtornos Globais do Desenvolvimento Infantil
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Alelos
/
República da Coreia
/
Genótipo
Tipo de estudo:
Prognostic_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2013
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
/
COREIA DO SUL
/
KR
/
SOUTH KOREA