Progress of KL-6 in pulmonary disease / 国际儿科学杂志

ABSTRACT

Krebs von den Lungen-6(KL-6) is a high-molecular-weight transmembrane mucin.In recent research,the levels of KL-6 in serum and bronchoalveolar lavage fluid are significantly higher in some pulmonary disease such as interstitial lung disease,acute lung injury,tumor and bronchopulmonary dysplasia.Consequently KL-6 is recommended as a reference index for early diagnosis,evaluation of therapeutic efficiency and outcome prediction.But the molecular mechanism of KL-6 in different diseases requires further research.