Effect of finasteride on bone mineral density in elderly patients with benign prostatic hyperplasia / 中华老年医学杂志

ABSTRACT

Objective To retrospectively investigate the effect of finasteride on bone mineral density in elderly patients with benign prostatic hyperplasia (BPH).Methods 120 elderly patients with BPH were retrospective studied in our hospital,and grouped into the finasteride group and the control group according to taking finasteride or not.Bone mineral density in all patients was measured by dual energy X-ray absorptiometry at baseline and 12-15 months after follow-up,and peripheral blood was collected for measuring serum biochemical indicators including calcium,phosphorus,creatinine and alkaline phosphatase (ALP).Results There were no significant differences in indexes of bone mineral density,serum calcium,phosphorus,creatinine and ALP between the finasteride group and the control group.Conclusions Finasteride may not increase the risk of osteoporosis in elderly patients with BPH.