Comparison of the chemical composition between fresh and dried venenum bufonis by UPLC-Orbitrap MS / 药学学报
Acta Pharmaceutica Sinica
; (12): 1446-50, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-457237
Biblioteca responsável:
WPRO
ABSTRACT
To identify the active components in Bufo melanostictus Schneider and clarify the difference between fresh and dried Venenum Bufonis, a UPLC-Orbitrap MS method has been established. The separation was performed with gradient elution of acetonitrile and water (with 0.1% formic acid) as mobile phase. By comparing their retention time and high resolution mass data of Venenum Bufonis extracts, 39 effective components were primarily identified by MS/MS analysis in positive ion mode. Twenty-six of them were bufadienolides. There were significant differences in the main composition between fresh and dried Venenum Bufonis. There are fewer bufadienolides in fresh toad venom.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo