The effect of Gegen Qinlian decoction on serum high sensitive C-reactive protein expression in rats with pe-riodontitis and atherosclerosis / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 180-183, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-460839
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To observe the effect of Gegen Qinlian decoction on serum high sensitive C-reactive protein(hs-CRP)expres-sion of rats with periodontitis and atherosclerosis(P-AS).Methods:
40 male Wistar rats were randomly divided into 2 groupscontrol group(A,n=1 0),P-AS group(B,n=30).5 rats in group A and B were used for the identification of P-AS model.Then rats with P-AS in group B were randomly divided into 5 groups(n=5)and administered with saline(B1 ),atorvastatin(B2),metronidazole (B3),atorvastatin+metronidazole(B4)and Gegen Qinlian decoction(B5)respectively for 4 weeks.Serum hs-CRP level was assayed by ELISA.Periodontal attachment loss(AL)and artery change were examined by pathology.Results:
Serum hs-CRP level in group B1-5 was higher than that of group A(P0.05.The inflammation of periodontal tissues in group B2-5 was improved more than that in group B1 .AL in group B4 and B5 were lower than that in other groups(P0.05.Histopathological observation of arteries re-vealed that there was no foam cell in group B4 and B5 ,the artery wall in group B4 and B5 was more even and muscle fibers were ar-ranged more regular.Conclusion:
Gegen Qinlian decoction may decreas serum hs-CRP expression and depress the development of pe-riodontitis and atherosclerosis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Journal of Practical Stomatology
Ano de publicação:
2015
Tipo de documento:
Artigo