Protective effects of limb remote ischemic postconditionting on ischemic stroke rats under hyperglycemia / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 780-784, 2015.
Article
em Zh
| WPRIM
| ID: wpr-463249
Biblioteca responsável:
WPRO
ABSTRACT
Aim To study the protective effects of limb remote ischemic postconditioning ( LRIP ) on is-chemic stroke rats under hyperglycemia and explore the mechanisms. Methods Rats were given 50% glucose (6 mL·kg-1 ) by intraperitoneal injection to get acute hyperglycemia model. Then middle cerebral artery oc-clusion ( MCAO) models were created. After blocking middle artery for 1. 5 h and reperfusion for 2 h, behav-ioral testing, infarct size of brain, NO concentration and SOD activity in the serum of those rats were detec- ted. Results LRIP could improve behavioral score, decrease the area of cerebral infarction, increase the concentration of NO and the SOD activity in serum of MCAO rats. Conclusion LRIP can relieve cerebral ischemia-reperfusion injury of MCAO rats under acute hyperglycemia.
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Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2015
Tipo de documento:
Article