Association Study Between the rs4373814 Polymorphisms of Calcium Channel Gene and the Susceptibility of Essential Hypertension in Han Population at Northeastern Area of China / 中国循环杂志
Chinese Circulation Journal
; (12): 661-664, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-465103
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To investigate the relationship between rs4373814 polymorphisms of calcium channel (CACNB2) gene and the susceptibility of essential hypertension (EH) occurrence in Han population at northeastern area of China.Methods:
A case-control study in Han population at northeastern of China was carried out and the research included 1998 participants as 2 groups EH group,n=1006 patients treated in our hospital, and Control group,n=992 subjects with normal blood pressure from physical examination. The rs4373814 polymorphisms were examined by Snapshot technique and the statistical analysis was performed by SPSS 19.0 software.Results:
The rs4373814 risk allele C frequency of CACNB2 gene was signiifcantly different between EH group and Control group,P=0.039, OR=1.068, 95% CI (1.004-1.137). Logistic regression analysis showed that with adjusted gender, age, BMI, smoking, drinking, in dominant model, the genotype rs4373814 carring CC + GC/GG obviously increased the risk of EH occurrence,P=0.037, OR=1.260, 95% CI (1.013-1.567).Conclusion:
The rs4373814 polymorphisms of CACNB2 gene are related to the susceptibility of EH occurrence in Han population at northeastern area of China.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Chinês
Revista:
Chinese Circulation Journal
Ano de publicação:
2015
Tipo de documento:
Artigo