Progress of research on mTOR inhibitor in endocrine and HER-2 targeted therapy resistance in breast cancer / 国际肿瘤学杂志
Journal of International Oncology
; (12): 377-380, 2015.
Article
em Zh
| WPRIM
| ID: wpr-467328
Biblioteca responsável:
WPRO
ABSTRACT
Mammalian target of rapamycin(mTOR)locates at the downstream of phosphatidylinositol 3 kinase(PI3K)-protein kinase B(Akt)cell signal transduction pathway. Studies find that the abnormal activa-tion of this pathway is correlated with the endocrine and drug resistance of anti human epidermal growth factor receptor-2(HER-2)target therapy in breast cancer. The combination with mTOR inhibitors based on the past traditional drugs can block the pathway and reflect a favourable application prospect in preventing the develop-ment of resistance and restoring the initial sensitivity on tumor cells. mTOR inhibitors are expected to be the new hope for the treatment of breast cancer.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of International Oncology
Ano de publicação:
2015
Tipo de documento:
Article