Design,synthesis and activity evaluation of new anti-HIV-1 CXCR4 inhibitors / 军事医学
Military Medical Sciences
; (12): 602-607, 2014.
Article
em Zh
| WPRIM
| ID: wpr-473988
Biblioteca responsável:
WPRO
ABSTRACT
Objective To design and synthesize a series of new type four hydrogen quinoline-benzyl/benzimidazole amine derivatives as a potential new inhibitor targeting auxiliary receptor CXCR 4, and determine their inhibitory activities to HIV-1.Methods Based on HIV-1 receptor CXCR4 inhibitors containing three nitrogen structure-activity motif and CCR5 partial hydrophobic pharmacophore , a series of new compounds were designed , synthesized and characterized by 1 HNMR and MS.The inhibitory activities of these compounds were determined using HIV-1 IIIB virus.Results and Conclusion Ten target compounds are synthesized .Four hydrogen quinoline-benzimidazole amine derivatives exhibit good anti-HIV activity(IC50 8 μmol/L).
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Military Medical Sciences
Ano de publicação:
2014
Tipo de documento:
Article