Clinical curative effect of budesonide inhalation in the treatment of children with Pneumonia / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of budesonide inhalation in the treatment of children with pneumonia.Methods 100 children with pneumonia were randomly divided into the two groups.The control group received conventional oral medication,the observation group was given Pulmicort Turbuhaler (budesonide)inhalation therapy.The clinical efficacy and respiratory function changes were observed after treatment for 1 week.Results In the observation group,cough,shortness of breath,body temperature stable,pulmonary rales disappearance,X-ray absorption of inflammation and the average healing time were (1.28 ± 1.04) d,(2.48 ± 0.39) d,(2.04 ± 0.22) d,(2.22 ± 0.43) d,(3.39 ± 0.35) d,(3.65 ± 0.39) d,which were significantly better than those in the control group [(2.62 ± 1.63)d,(4.85 ± 1.38)d,(4.85 ± 1.31)d,(4.63 ±0.84)d,(5.53 ±0.82)d,(5.58 ±1.20) d(t =2.62,1.86,3.72,1.46,1.68,2.71,all P ＜0.05].In the observation group,the FEV1,PEF,FEF50％,FVC before treatment were (70.24 ± 10.46) L,(70.05 ± 12.86)L/s,(66.74 ± 11.77) ％,(67.16 ± 11.98) ％,after treatment were (90.14 ± 12.63) L,(92.64 ± 10.75) L/s,(84.56 ± 15.12) ％,(81.65 ± 13.96) ％,after treatment the indicators were significantly improved (t =2.34,4.83,1.89,3.27,all P ＜ 0.05).In the control group,before treatment,the FEV1,PEF,FEF50％,FVC were (70.56 ±9.95) L,(70.17 ± 13.58) L/s,(66.45 ± 11.58)％,(67.44 ± 12.37) ％,after treatment were (78.76 ± 11.44) L,(79.46 ± 14.36) L/s,(70.24 ± 12.39) ％,(72.03 ± 12.47) ％,after treatment all indicators were significantly improved (t =3.15,2.67,4.16,2.34,all P ＜ 0.05).The improvement of lung function in the observation group was significantly better than the control group (t =2.64,2.85,1.58,2.72,P ＜ 0.05).The effective rate of the observation group was 92％,which was significantly higher than 72％ of the control group (x2 =6.7 5 5,P ＜ 0.0 5).Conclusion Pulmicort Turbuhaler inhalation in the treatment of children with pneumonia can significantly relieve airway hyperresponsiveness,improve treatment effect,improve respiratory function.