A meta-analysis of stroke risk in type 2 diabetic patients treated with sulfonylurea / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 758-764, 2015.
Article
em Zh
| WPRIM
| ID: wpr-478754
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate whether sulfonylurea ( SU) increases the risk of stroke in patients with type 2 diabetes mellitus(T2DM). Methods A systemic meta-analysis including 17 random control trails(RCT) was performed to compare the risk of stroke between type 2 diabetic patients treated with SUs and comparators. Results 1 612 articles were retrieved, and finally 17 articles were included. Patients receiving SUs treatment had a higher relative risk of stroke (RR 1. 35, 95% CI 1. 13-1. 60) than those who received comparators. The I2 statistic for heterogeneity between 17 trails was 0. 0%(P=0. 687). No major asymmetry appeared in the funnel plot and Begg′adjusted rank correlation test(kendall′s score=22, P=0. 387). Conclusion The use of SUs may raise the risk of stroke which is already high in patients with T2DM.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Etiology_studies
/
Systematic_reviews
Idioma:
Zh
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2015
Tipo de documento:
Article