FoxOs and osteoporosis / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 169-171, 2016.
Article
em Zh
| WPRIM
| ID: wpr-487734
Biblioteca responsável:
WPRO
ABSTRACT
As one subclass of forkhead proteins, the forkhead box O ( FoxO) transcription factors take part in a series of bio-logical processes including cellular apoptosis, damaged DNA re-pair and cleavage of reactive oxygen species(ROS). Increasing evidence highlights that oxidative stress elicited by FoxOs con-tributes to imbalance of redox status in cells related to bone me-tabolism, resulting in development of the pathogenesis of osteo-porosis. This article reviews the relationship of FoxOs and osteo-porosis, which may be beneficial for the research of pathological mechanism and therapeutic strategy of osteoporosis.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2016
Tipo de documento:
Article