Clinical efficacy of combination therapy of Tamsulosin plus Tolterodine sustained-release capsules on benign prostatic hyperplasia with overactive bladder in elderly men / 中华老年医学杂志
Chinese Journal of Geriatrics
; (12): 533-536, 2016.
Article
em Zh
| WPRIM
| ID: wpr-496649
Biblioteca responsável:
WPRO
ABSTRACT
Objective To evaluate the efficacy of combination therapy of cholinergic receptor blocker Tolterodine and Alpha-adrenergic receptor blocker Tamsulosin sustained-release capsules on benign prostatic hyperplasia(BPH)with overactive bladder(OAB) in elderly men.Methods A total of 97 male BPH patients aged 80 years and over(80~98 years old,mean 87.7 years old)were enrolled in this study,who met the diagnosis and treatment guidelines of OAB formulated by Chinese Urological Association and were admitted to our hospital from Jan.2015 to July.2015.Patients were randomly divided into Tamsulosin group(n= 51,treated with Tamsulosin) and combination group(n= 46,treated with Tamsulosin and Tolterodine).Results In Tamsulosin group after treatment,the international prostate symptom score(IPSS) was reduced from (18.3 ± 2.7) to (13.3 ± 3.1) (t = 14.94,P < 0.05),OAB symptom score(OABSS) from (9.3 ± 2.7) to (6.8 ± 1.9) (t = 3.92,P < 0.05),and post void residual volume(PVRV)from(36.5±32.3)ml to(16.2±12.1)ml(t=14.98,P<0.01).And the daily frequency of urgency,urgency incontinence and nocturia were improved in Tamsulosin group after treatment.IPSS,OABSS and PVRV were improved more significantly in combination group after treatment than in Tamsulosin group,and the daily frequency of urgency,urgency incontinence and nocturia were reduced more significantly in combination group than in tamsulosin group(t=-5.23,-3.98,9.01,11.5,14.8,P<0.01).While there was no significant difference in prostate volume (PV)and PVRV between the two groups after 8 weeks of treatment(t= 1.22,-0.94,P>0.05).The total incidences of adverse events (mainly mouth dryness)had no significant differences between the Tamsulosingroup and the combination group(8.7% vs.5.9%,x2 =99.47,P>0.05).No acute urinary retention was found in the two groups.Conclusions The combination therapy of Tamsulosin and Tolterodine has better efficacy and safety than single Tamsulosin application in the treatment of BPH with OAB in elderly men.
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Base de dados:
WPRIM
Tipo de estudo:
Guideline
Idioma:
Zh
Revista:
Chinese Journal of Geriatrics
Ano de publicação:
2016
Tipo de documento:
Article