Serum uric acid and lifestyle factors associated with the risk of Parkinson's disease / 中华神经科杂志

ABSTRACT

Objective To investigate the relationship between serum uric acid (UA)levels and Parkinson's disease (PD) risk under specific lifestyle exposures.Methods Case-control study was used.Three hundred and ninety-seven PD cases and the same number of controls with matched age and gender were selected.Demographic and exposure information was collected by face-to-face interview,and blood biochemistry studies tested.Logistic regression model was used to analyze the association of PD risk with UA levels or enviromental factors.Results The highest value of UA levels was associated with a decreased PD risk compared to the lowest value (OR =0.39,95％ CI 0.25-0.63) in both male and female groups.This association was significant among nonsmokers (OR =0.52,95％ CI 0.32-0.76),nondrinkers (OR =0.4,95％ CI 0.34-0.70),and persons taking exercise more than 1 houre a day (OR =0.51,95％ CI 0.35-0.74).But no significant association was affected in the subjects with smoking or drinking history and those with less exercise (＜ 1 hour a day).Conclusion We confirmed that higher UA levels were associated with lower PD risk in Chinese population,and some lifestyles may modify the protection effect of serum UA.