Efficacy and its related factors of phenobarbital treatment for epilepsy management in rural China / 中华全科医师杂志
Chinese Journal of General Practitioners
; (6): 687-692, 2016.
Article
em Zh
| WPRIM
| ID: wpr-502067
Biblioteca responsável:
WPRO
ABSTRACT
Objective To analyze efficacy and its influencing factors of phenobarbital treatment for epilepsy management in rural China.Methods Total 3 315 patients with convulsive epilepsy from rural areas of 24 counties were enrolled in this joint epilepsy management program.All patients received phenobarbital monotherapy for 1 year during November 2011 to November 2013.The efficacy and potential influencing factors including sex,age,duration of epilepsy,number of seizures in the 12 months before management(≥2),previous treatment,daily dose of phenobarbital,taking other antiepileptic drugs and compliance of patients were studied with multivariate analysis.Results Among 3 315 patients,38.9% were seizure-free during the entire management period.The rates of seizure-free in 15 to 39 y age group (35.2%,495/1 405)and in patients receiving irregular treatment previously (34.6%,625/1 808)were lower.The rates of seizure-free were higher in patients taking phenobarbital 60-90 mg everyday (49.4%,988/2 000) and those with good compliance(42.3%,1 160/2 744).Patients taking other antiepileptic drugs in 12 months had lower seizure-free rate (31.0%,45/145).Univariate analysis showed that gender of patients was not related to seizure-free rate (P > 0.1).Multivariate analysis showed that the longer duration of epilepsy(OR =0.015,95% CI:1.008-1.021,P < 0.001),more seizures in the 12 months (OR =0.005,95% CI:1.002-1.007,P =0.002) and the irregular treatment before management were the risk factors for low seizure-free rate (P < 0.05).Patients received formal treatment or untreated had a lower risk of seizure compare with the irregular treatment (OR =0.737,95% CI:0.611-0.889,P =0.001;OR =0.566,95% CI:0.469-0.683,P <0.001).Patients with good compliance and with a daily dose of 60-89 mg phenobarbital(OR =0.107,95% CI:0.013-0.905,P =0.040) were associated with high seizurefree rate;in contrast the poor compliance was a risk factor for not being seizure-free(OR =2.038,95% CI:1.634-2.541,P < 0.001).Conclusion Regular medication of phenobarbital with good compliance is effective for convulsive epilepsy management in rural China.
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Base de dados:
WPRIM
Tipo de estudo:
Risk_factors_studies
Idioma:
Zh
Revista:
Chinese Journal of General Practitioners
Ano de publicação:
2016
Tipo de documento:
Article