Analysis of the Patients with Indeterminate Results by Anti-HIV Western Blot Assay: Experience of a University Hospital During Recent 5 Years in Korea / 임상검사와정도관리
Journal of Laboratory Medicine and Quality Assurance
; : 49-55, 2011.
Article
em Ko
| WPRIM
| ID: wpr-50878
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Interpretation of indeterminate results by anti-HIV Western blot assay, which is currently used as a confirmatory test for HIV infection, can be usually difficult. We analyzed outcomes of the patients with indeterminate results by anti-HIV Western blot.METHODS:
Medical records of patients, who were indeterminate by the anti-HIV Western blot assay in a university hospital during recent 5 years, were retrospectively reviewed. HIV screening test was performed by chemiluminescent immunoassay autoanalyzer (Abbot Laboratories, USA) with HIV Ag/Ab Combo kits. Confirmatory Western blot assay for the positive samples by HIV screening test was committed to the Korean National Institute of Health.RESULTS:
A total of 202,639 specimens were tested for HIV screening during the period, and 644 (0.32%) sera showed positive results. Among these, 46 (7.1%) cases were indeterminate by the Western blot, which were from 20 patients, and 13 of them converted to be anti-HIV positive, and 3 were lost to follow-up. Another four patients were turned out to be negative for HIV infection, including two neonates from HIV-positive mothers receiving antiviral treatment during pregnancy.CONCLUSIONS:
Most of the patients who showed Western blot-indeterminate results converted to HIV positive after follow-up. Thus, careful monitoring of patients with indeterminate Western blot results should be essential.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Imunoensaio
/
Infecções por HIV
/
Programas de Rastreamento
/
Prontuários Médicos
/
Western Blotting
/
Estudos Retrospectivos
/
Seguimentos
/
HIV
/
Perda de Seguimento
/
Coreia (Geográfico)
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Humans
/
Newborn
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Journal of Laboratory Medicine and Quality Assurance
Ano de publicação:
2011
Tipo de documento:
Article