The Efficacy of Amniotic Membrane Graft in the Treatment of Symptomatic Bullous Keratopathy
Journal of the Korean Ophthalmological Society
; : 1036-1040, 2007.
Article
em Ko
| WPRIM
| ID: wpr-51004
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To evaluate the efficacy of amniotic membrane (AM) transplantation in symptomatic bullous keratopathy using cryo-preserved or lyophilized AM.METHODS:
Eight bullous keratopathic patients, who experienced intractable pain despite medication and the application of a therapeutic lens, underwent permanent AM transplantation with 5 cryo-preserved and 3 lyophilized AMs following removal of epithelium using a trephine. The time to re-epithelization and the subsidence of pain were evaluated retrospectively.RESULTS:
Mean follow-up was 252+/-171.0 days. Pain relief and re-epithelization were obtained in all eight patients. The times to complete relief of pain was 32.2+/-22.7 days in patients with cryo-preserved AM transplantations (n=5) and 22.0+/-18.0 days in those with lyophilized AM transplantations (n=3) (p=0.549, Mann-Whitney U test). Respective times to re-epithelization were 25.4+/-20.7 days and 23.0+/-25.2 days (p=0.297). There were no significant differences in the diameter of transplanted AMs between the two groups (7.6+/-0.2 vs. 7.3+/-0.3 mm, p=0.172).CONCLUSIONS:
Permanent AM transplantation effectively reduced the intractable pain caused by epithelial bulla. Whether the AM was cryo-preserved or lyophilized did not affect the efficacy of the treatment.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Dor Intratável
/
Estudos Retrospectivos
/
Seguimentos
/
Transplantes
/
Epitélio
/
Âmnio
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2007
Tipo de documento:
Article