Effects of lofexidine on the pharmacokinetics of morphine in rats / 中国法医学杂志
Chinese Journal of Forensic Medicine
; (6)1988.
Article
em Zh
| WPRIM
| ID: wpr-517365
Biblioteca responsável:
WPRO
ABSTRACT
The pharmacokinetics of morphine in rats was studied after treatment with morphine, as well as morphine and lofexidine. The results showed that in lofexidine group the T 1/2ka and CL of morphine was significantly increased, while the C max ,AUC and T 1/2k of morphine were significantly decreased. Our results indicate that the lofcxidine can reduce the absorption rate of the morphine and the concentration of morphine in blood, and then can increase the total clearance rate of morphine in rats.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Forensic Medicine
Ano de publicação:
1988
Tipo de documento:
Article