Effects of Carvedilol on Blood Pressure in Hypertensive Patients and Vascular Endothelial Function / 中国药房
China Pharmacy
; (12)2007.
Article
em Zh
| WPRIM
| ID: wpr-534532
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the effects of carvedilol on blood pressure in hypertension patients and vascular endothelial function.METHODS:
100 inpatients with primary hypertension were collected from our hospital from Jan. 2008 to Jan. 2010 and randomly divided into treatment group and control group(n=50). Treatment group were given initial oral dose of carvedilol tablets 6.25 mg twice a day for 7~14 days if it was tolerated; the dose of carvedilol tablets increased to 12.5 mg or 25 mg twice a day according to blood pressure at trough concentration if it was necessary. Control group were given carvedilol tablets 6.25 mg twice a day if it was tolerated. After 1 week, control group received double dose of metoprolol with maximum dose of carvedilol of 50 mg. The treatment course was 3 months. The contents of NO and ET in serum of 2 groups were detected. Antihypertensive effect and effects of carvedilol on vascular endothelial dilatation and systolic function were observed and compared between 2 groups.RESULTS:
After treatment, the systolic and diastolic blood pressure in both groups were decreased significantly(P
Texto completo:
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2007
Tipo de documento:
Article