THE ALTERATION OF LOCAL AND CIRCULATING RENIN-ANGIOTENSIN SYSTEM(RAS) DURING MECHANICAL-OVERLOAD CARDIAC HYPERTROPHY OF RATS / 西安交通大学学报(医学版)

ABSTRACT

We studied the alteration of local and circulat-ing RAS during cardiac hypertrophy caused by ab-dominal aorta constriction (AC, with nephrectomyof left side) and aorta-vena fistula (AVF). Bothventricular and plasma angiotensin Ⅰ and Ⅱ (AngⅠ. Ⅱ), and plasma, renin actvity (RA) weremeasured by means of radioimmunoassay after twoand seven weeks of surgery. Despite the level ofplasma Ang Ⅰ, Ⅱ and RA were not enhanced, theventricular Ang Ⅰ and Ⅱ were increased signifi-cantly in AC rats (v. s. SO group P