Correlation between chlamydia pneumoniae infection and acute myocardial infarction / 中华老年医学杂志

ABSTRACT

Objective To investigate the correlations between chlamydia pneumoniae (Cpn) infection and acute myocardial infarction(AMI). Methods Specific antibodies and DNA to Cpn were measured in 51 patients with AMI(AMI group),42 patients with elderly myocardial infarction (OMI group) and 31 normal controls (NC group), 33 patients(UC group)who had no angiographic evidence of coronary artery disease. Moreover,the levels of fibrinogen(Fg),6-ketoprostaglandin f1alpha(6-Keto-PGF1?),thromboxane B2(TXB2) and P-selection(GMP 140) were determined in the four groups. Results The prevalence of Cpn IgG antibody was associated with AMI(OR 3.65).Adjustment for the major cardiovascular risk factors did not attenuate this correlation(OR 3.17). Those who were Cpn positive in the AMI group had significantly higher levels of Fg,TXB2 and GMP 140, and a significantly lower level of 6-Keto-PGF1? than those who were Cpn negative in the same group.Correlation analysis revealed that the average concentration of IgG antibody to Cpn was positively associated with the levels of Fg,TXB2 and GMP140 but negatively associated with the level of 6-Keto-PGF1? in the Cpn positive patients of the AMI group. Conclusions There is a significant correlation between Cpn infection and AMI. Cpn infection is associated with the levels of Fg,TXB2, 6-Keto-PGF1? and GMP140 in plasma.