The development of FOXO3a in breast cancer / 中国癌症杂志

ABSTRACT

FOXO3a is an important member of the forkhead box family. The expression of FOXO3a is correlated with cell transformation, tumor development and angiogenesis. FOXO3a inhibited tumor cell growth and progression through upregulation of the expression of Bim, p27Kip1 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The activation of FOXO3a is modulated by Akt, I?K? and oxidative stress. It has been demonstrated that FOXO3a was closely related to some generally accepted prognostic factors. Therefore, FOXO3a may become a new prognostic factor of breast cancer. This review focused on the structure of FOXO3a, the role of FOXO3a expression on breast cancer and the relationship between FOXO3a and the generally accepted prognostic factor of breast cancer.