Impact of preemptive cytomegalovirus infection on renal transplantation / 第三军医大学学报

ABSTRACT

Objective To investigate the effect of preemptive cytomegalovirus infection(CMV) on acute rejection (AR) and assess the value of preemptive prophylactic antivirus therapy. Methods Retrospective study of 116 transplant recipients from September 2001 to February 2005 was made. The CMV infection was diagnosed by CMV-PP65 antigen tests. According to the result of CMV-PP65 antigen, 116 transplant recipients were divided into preemptive CMV infected group and non-infected group. The preemptive CMV infected recipients were subdivided into valacyclovir-treated group and non-valacyclovir-treated group. The impact of preemptive cytomegalovirus infection on acute rejection was analyzed. At the same time, CMV-PP65 antigen in 35 healthy subjects was detected. Results Seventy-four recipients had preemptive CMV infection, and the infection rate of renal transplant recipients was higher than healthy subjects (63.8% vs 14.3%, P