Development of cancer stem cell / 国际生物医学工程杂志

ABSTRACT

According to traditional theory tumor growth arised from the proliferation of all tumor cells, therefore management mainly aimed at the majority of the cells within cancer tissue. As a result, relapse and metastasis developed often, which caused treatment failure. It was stem cell that makes it possible to treat cancer radically and prevent it from relapsing and metastasizing by specifically killing targeted cancer stem cells and even some old concepts such as tumorigenesis mechanism, cell signaling pathways etc may need to be reevaluated, that raised great challenge to traditional oncotherapy. In this text the origin and existing evidence of cancer stem cell, it's relationship to common stem cell, clinical significance and prospect were reviewed.