Effect of angiotensin( 1 -7) on left ventricular hypertrophy and myocardial fibrosis in 2K1C and INAC hypertensive models / 第三军医大学学报

ABSTRACT

Objective To determine the effect of angiotensin( 1 -7) [Ang( 1 -7) ]on the left ventricular hypertrophy and myocardial fibrosis in a pressure-overload hypertensive models,infra-nephric aorta coarctation ( INAC) ,and a renin-angiotensin-aldosterone system ( RAAS) activation hypertensive model,two kidney one clip ( 2K1C) in the early and late stage. Methods Totally 120 health male Wistar rats were randomly and equally divided into 6 groups,that is,sham INAC group,INAC group,INAC Ang( 1 - 7) group,sham 2K1C group,2K1C group and 2K1C Ang( 1 -7) group. INAC and 2K1C hypertensive models was established to cor- responding groups and osmotic minipump implantation was carried out to the rats to deliver the Ang( 1 - 7) to their body homogenously and to examine the parameters representing the blood pressure,including left ventricu- lar hypertrophy ( LVW,LVI,CA) and myocardial fibrosis ( CVF and PVCA) . Results Left ventricular hy- pertrophy ( LVH) was observed in the early stage and developed in the late stage both in the 2K1C and INAC groups. Ang( 1 -7) decreased LVW,LVI,CA both in the early and late stage in the 2K1C model( P 0. 05) . Myocardial fibrosis happened and developed progressively in the 2K1C hypertensive model ( P 0. 05) . There was a mild myocardial fibrosis happened in the left ventricle of the INAC model in the late stage( P