Estrogen receptor ? (ER?) gene polymorphism of perimenopausal syndrome patients with liver qi stagnation syndrome (LQSS) / 中华中医药杂志
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-567732
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To investigate the association between polymorphisms of estrogen receptor ? (ER?) gene (rs3020444) and perimenopausal syndrome (PS) in patients with liver qi stagnation syndrome (LQSS). MethedsThe ER?T/C genotype in 100 patients of PS of LQSS type (PS-LQSS group),86 patients of PS of non-LSDS type (PS-non-LQSS group) and 100 healthy subjects (control) was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay.Results:
Partitions of ?2 method showed that the higher prevalence of ER?-TT genotypes was noted in PS-LQSS group (?2=8.307,P=0.004),and the higher prevalence of T alleles was noted in PS-LQSS group (?2=7.129,P=0.008). and Multinomial logistic-regression indicated that the odds ratios (OR) of the ER?-TT genotypes vs TC/CC for PS-LQSS was 2.222 (95%CI1.172-4.744,P=0.015) after adjusting for common miscellaneous factors.Conclusions:
It was suggested that ER?-TT genotypes was significantly associated with PS-LQSS,and ESR?-TT may be one of the genes that contribute to PS-LQSS.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Journal of Traditional Chinese Medicine and Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo