Comparison of Protective Mechanism of Zuojin Pill and Fan Zuojin Pill on Gastric Mucosa / 广州中医药大学学报
Article
em Zh
| WPRIM
| ID: wpr-571244
Biblioteca responsável:
WPRO
ABSTRACT
[ Objective] To compare the protective mechanism of Zuojin Pill (Rhizoma Coptidis Fructus Evodiae = 61) and Fan Zuojin Pill (Rhizoma Coptidis Fructus Evodiae = 1 6) on gastric secretion and gastric mucosal barrier. [Methods] Pylorus - ligated rat model was applied. Rats were divided into normal saline group, Zuojin Pill groups (1.4 g/kg and 2.8 g/kg) and Fan Zuojin Pill groups (1.4g/kg and 2.8g/kg) and then the drugs were given by duodenal feeding. Gastric secretion and gastric mucus synthesis were examined. [Results] Zuojin Pill and Fan Zuojin Pill (1.4 g/kg and 2.8 g/kg) both inhibited gastric secretion and decreased total acid output and pepsin activity in a dose- effect manner. Zuojin Pill and Fan Zuojin Pill also increased the content of gastric adherent mucus (GAM) and tended to elevate the mucus level in gastric juice. [Conclusion] The preventive mechanism of Zuojin Pill and Fan Zuojin Pill on gastric mucosa may be related to the regulation of gastric secretion and gastric mucus synthesis.
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1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Guangzhou University of Traditional Chinese Medicine
Ano de publicação:
1999
Tipo de documento:
Article