Effects of Xiaofeng Powder on IL-4,IFN-? and sIL-2R in Delayed Hypersensitivity / 中国中医药信息杂志

ABSTRACT

Objective To study the effects of Xiaofeng Powder on IL-4,IFN-? and sIL-2R in delayed hypersensitivity and to explore the mechanism of treatment. Methods The mice model of allergic contact dermatitis was formed by DNCB. The effect of Xiaofeng Powder on ear swelling and leukocyte counts of the model mice were observed. The serum levels of interleukin-4 (IL-4),interferon-gamma (IFN-?) and soluble interleukin-2 receptor (sIL-2R) of the mice were detected by enzyme-linked immunosorbent assay (ELISA). Results Xiaofeng Powder could inhibit ear swellings and obviously reduced the total amount of leucocytes. Xiaofeng Powder could heighten IL-4 level and reduce the level of IFN-?,sIL-2R. Conclusion Xiaofeng Powder has the function of inhibiting delayed hypersensitivity. The mechanism of treatment may be related to inhibiting the total amount of leucocytes,regulating cell factor and receptor.