The research of serum-DNA IgH and T-cell receptor gama gene rearrangement in lymphogenous malignant patients / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
; (12)2003.
Article
em Zh
| WPRIM
| ID: wpr-587626
Biblioteca responsável:
WPRO
ABSTRACT
Objective To evaluate the diagnostic significance of detecting serum-DNA concentration and clonal gene rearrangement in lymphogenous malignant patients.Methods Serum-DNA in 72 diagnosed patients were measured and analyzed by SPSS11.0.Serum and mono-nuclear cells samples were collected. IgH CDRⅢ, TCR?V9 region were amplified by PCR.Results The serum-DNA concentration of disease groups were (418?172)?g/ml,(426?192)?g/ml, (388?170)?g/ml and(400?110)?g/ml, each was higher than those of control group(77?47)?g/ml(P0.05).Conclusion The concentration of serum-DNAwere higher in lymphogenous malignant patients and tumor associated DNA could be easily detected, so they have important diagnostic value in lymphogenous malignant patients.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Laboratory Medicine
Ano de publicação:
2003
Tipo de documento:
Article