Found in Inflammatory Zone 1 Enhance Scavenger Receptor-A Expression in Vascular Smooth Muscle Cells / 中华高血压杂志
Chinese Journal of Hypertension
; (12)2006.
Article
em Zh
| WPRIM
| ID: wpr-590323
Biblioteca responsável:
WPRO
ABSTRACT
Background Found in Inflammatory Zone 1(FIZZ1)is a newly found protein associated with pulmonary inflammation.We previously had reported its role in the development of atherosclerosis,but its detailed mechanism has not been explored.Objective This study was designed to delineate the effect of FIZZ1 on the expression of scavenger receptor(SR-A)in vascular smooth muscle cells(VSMC)scavenger receptor(SR-A)induced by ox-LDL.Methods Smooth muscle cells were treated with ox-LDL(20 mg/L)or cocultured with recombinate FIZZ1 at different concentration(final concentration 3?10-6,9?10-6,2.7?10-5 mmol/L).The expression of SR-A of smooth muscle cell was detected by flow cytometry and laser confocal microscopy.Results SR-A positive expression was found in VSMCs treated with ox-LDL after 24 hours,which were located mainly in cell membrane by laser confocal microscopy.FIZZ1 significantly accentuate the LDL induced increases in SR-A positive rate in VSMC in a dose dependent manner(P
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Hypertension
Ano de publicação:
2006
Tipo de documento:
Article