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Changes and significance of inflammation factors in model rabbit with artherosclerosis induced by hyperhomocysteic acid / 吉林大学学报(医学版)
Article em Zh | WPRIM | ID: wpr-591258
Biblioteca responsável: WPRO
ABSTRACT
Objective To study the relationship between hyperhomocysteic acid(HHcy) and artherosclerosis.Methods 20 male rabbits were randomly divided into control and experiment groups(n=10).HHcy models were made by hypodermical injection of DL-methionine for 7 weeks.After 7 weeks homocysteic acid(Hcy),IL-1?,IL-6,and IL-8 in serum of rabbits in two groups were measured by enzyme linked immunosorbent assay(ELISA).And the pathomorphological changes of aorta were observed with HE staining.The number of NF-?B positive cells in the aorta were counted by immunohistochemical method.Results The levels of Hcy,IL-1?,IL-6 and IL-8 in experiment group were higher than those in control group(P
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Texto completo: 1 Base de dados: WPRIM Tipo de estudo: Prognostic_studies Idioma: Zh Revista: Journal of Jilin University(Medicine Edition) Ano de publicação: 2006 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Tipo de estudo: Prognostic_studies Idioma: Zh Revista: Journal of Jilin University(Medicine Edition) Ano de publicação: 2006 Tipo de documento: Article