Relationship Between Immediate ?-Lactam Allergy and Polymorphism of Interleukin-10 Gene / 中华医院感染学杂志
Chinese Journal of Nosocomiology
; (24)2006.
Article
em Zh
| WPRIM
| ID: wpr-592104
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE To investigate the association between 592C/A and-819C/T of interleukin-10 gene polymorphism in patients with immediate ?-lactam drug allergy in Chinese Han population.METHODS The genotype and allele frequency of interleukin-10 gene were studied by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)in 44 Chinese Han patients with evidence of immediate ?-lactam drug allergy and 44 controls subjects.They all matched for sex and atopy,the production was investigated by sequence analysis.RESULTS Our analysis did reveal differences in the distribution of the single nucleotide polymorphism(SNP)between female allergic patients and controls.Among allergy subjects,we found two distinct significant associations between immediate drug allergy women and two linked IL-10 promoter genes polymorphism,-592C/A and-819C/T(P
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Nosocomiology
Ano de publicação:
2006
Tipo de documento:
Article