A Case of Pyrazinamide Induced Fulminant Hepatic Failure / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 435-439, 2007.
Article
em Ko
| WPRIM
| ID: wpr-59557
Biblioteca responsável:
WPRO
ABSTRACT
Standard antituberculous therapy, including isoniazid (INH), rifampin, ethambutol, and pyrazinamide (PZA), is widely used to treat active tuberculosis. The most important side effect is hepatotoxicity. In a standard four-drug regimen, PZA was the most common cause of drug-induced hepatitis and was dose-related. The incidence of drug-induced hepatitis is high at doses of 40~70 mg/kg per day but has fallen significantly since the recommended dose was reduced. Liver toxicity induced by PZA is rare at doses of 25 mg/kg per day or less. PZA-induced fulminant hepatic failure is also rare but fatal. We report a case of fulminant hepatic failure caused by a re-challenge of PZA.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pirazinamida
/
Rifampina
/
Tuberculose
/
Incidência
/
Falência Hepática Aguda
/
Etambutol
/
Doença Hepática Induzida por Substâncias e Drogas
/
Isoniazida
/
Fígado
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2007
Tipo de documento:
Article