Comparison of Invariant NKT Cells with Conventional T Cells by Using Gene Set Enrichment Analysis (GSEA)
Immune Network
; : 406-411, 2011.
Article
em En
| WPRIM
| ID: wpr-60132
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Invariant Natural killer T (iNKT) cells, a distinct subset of CD1d-restricted T cells with invariant Valphabeta TCR, functionally bridge innate and adaptive immunity. While iNKT cells share features with conventional T cells in some functional aspects, they simultaneously produce large amount of Th1 and Th2 cytokines upon T-cell receptor (TCR) ligation. However, gene expression pattern in two types of cells has not been well characterized. METHODS: we performed comparative microarray analyses of gene expression in murine iNKT cells and conventional CD4+CD25-gammadeltaTCR- T cells by using Gene Set Enrichment Analysis (GSEA) method. RESULTS: Here, we describe profound differences in gene expression pattern between iNKT cells and conventional CD4+CD25-gammadeltaTCR- T cells. CONCLUSION: Our results provide new insights into the functional competence of iNKT cells and a better understanding of their various roles during immune responses.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Receptores de Antígenos de Linfócitos T
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Linfócitos T
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Expressão Gênica
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Citocinas
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Competência Mental
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Células T Matadoras Naturais
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Imunidade Adaptativa
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Ligadura
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2011
Tipo de documento:
Article