Study on the treatment of osteonecrosis of the femoral head in rabbits by absorbable bioactive bone-inducing material / 国际生物医学工程杂志

ABSTRACT

Objective To observe the outcome of an absorbable bioactive bone-inducing material for the treatment of osteonecrosis of the femoral head (ONFH).Methods Thirty rabbits were randomly,evenly divided into three groups,experience group with bioactive bone-inducing material planted into bone collapse,control group 1 with oral ShengMaiJiaoNang and control group 2 with no implantation in the bone necrosis.Results In experiment group,bone necrosis was halted and the collapse was repaired.Meanwhile,cancellous bone and cortical bone were regenerated,necrotic bone was basically healed,and bioactive bone-inducing material was gradually degraded and absorbed.In control group 1,part of the bone marrow vascular was repaired and regenerated,and a little new bone grew,which delayed the process of necrosis.In control group 2,there was no bone tissue regeneration in the bone collapse and further deterioration was observed.Conclusions The bioactive bone-inducing material can not only replace autologous cancellous bone,but also halt the progress of osteonecrosis,which may become an alternative treatment for the stage Ⅱ and early stage of ONFH.