Content Determination of Ethacridine Lactate in Compound Ethacridine Ointment by HPLC / 中国药房
China Pharmacy
; (12): 2109-2110,2111, 2016.
Article
em Zh
| WPRIM
| ID: wpr-605666
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WPRO
ABSTRACT
OBJETCTIVETo establish a method for the content determination of ethacridine lactate in Compound ethacridine ointment. METHODS:
HPLC was performed on the column of Agilent ZORBAX SB-C18 with mobile phase of 0.1% Octanesulfon-ic acid sodium solution-acetonitrile(70∶30,V/V)at a flow rate of 1.0 ml/min,the detection wavelength was 270 nm,the column temperature was 30℃,and the injection volume was 10 μl.RESULTS:
The linear range of ethacridine lactate was 10.002-50.010μg/ml(r=0.999 9);RSDs of precision,stability and reproducibility tests were less than 1%;recovery was 98.96%-100.36%(RSD=0.49%,n=9).CONCLUSIONS:
The method is simple,accurate and reproducible,and can be used for content determina-tion of ethacridine lactate in Compound ethacridine ointment.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2016
Tipo de documento:
Article