Prognosis of metabolic volume parameters by 18 F-FDG PET/CT in stage Ⅱ-Ⅲ non-small cell lung cancer / 中国医学影像技术

ABSTRACT

Objective To evaluate the prognostic value of 18F-FDG PET/CT-based metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in stage Ⅱ-Ⅲ non-small cell lung cancer (NSCLC).Methods All of 47 patients with pathological stage on Ⅱ or Ⅲ NSCLC who underwent PET/CT before treatment were retrospectively reviewed.Kaplan-Meier method,Log-rank test and COX proportional hazard model were used to analyze the relationship between metabolic parameters and overall survival (OS),progression free survival (PFS).MTV were measured using a cutoff of 40％ maximum standard uptake value (SUVmax).Results The median OS and PFS was 28.93 and 17.37 months,and the 1-,2 and 3-year overall survival rate was 80.85％ (38/47),59.57％ (28/47),38.30％ (18/47),respectively.Univariate analysis suggested that SUV MTV and TLG had significant differences on OS and PFS (all P＜0.05).On multivariate analysis,TLG was a risk factor for PFS (HR=5.591,P＜0.001),and MTV was a risk factor for OS (HR=4.369,P＜0.001).MTV was correlated with TNM-staging (r=0.449,P =0.012).Conclusion In patients with stage Ⅱ or Ⅲ NSCLC,MTV is a independent significant prognostic factor for OS,and TLG is able to predict the progression.