Changes and clinical significance of peripheral white blood cells in patients with acute and chronic human brucellosis / 中华地方病学杂志
Chinese Journal of Endemiology
; (12): 318-322, 2017.
Article
em Zh
| WPRIM
| ID: wpr-614578
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore characteristics and significance of the indexes of peripheral white blood cell (WBC) in patient with human brucellosis.Methods People checked by brucellosis physical checkup and routine physical checkup at Qiqihar Center for Disease Control and Prevention from December 2014 to December 2015,including 40 acute brucellosis patients (acute group),35 chronic brucellosis patients (chronic group) and 72 healthy people (control group),were selected.Automatic blood analyzer was used to determine the indexes of WBC,lymphocyte count (LY),lymphocyte percentage (LY%),monocytes count (MONO),monocytes percentage (MONO%),eosinophil count (EO),eosinophil percentage (EO%),basophilic granulocyte count (BASO),basophilic granulocyte percentage (BASO%),neutrophils count (NEUT) and neutrophils percentage (NEUT%).The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of WBC parameters in acute and chronic groups.Results Compared to control group,the levels of WBC,EO,EO%,BASO,BASO%,NEUT and NEUT% were decreased in acute group [(5.222 0-± 2.551 2) × 109/L vs (6.352 5 ± 1.905 8) × 109/L,(0.030 0 ± 0.006 8) × 109/[,vs (0.083 9 ± 0.039 3) × 109/L,(0.54 ± 0.12)% vs (2.31 ± 0.14)%,(0.009 0 ± 0.001 1) × 109/L vs (0.019 0 ± 0.002 4) × 109/L,(0.17 ± 0.09)% vs (0.32 ± 0.20)%,(2.698 7 ± 1.948 4) × 109/L vs (4.012 9 ± 1.579 0) × 109/L,(48.13 ± 14.38)% vs (62.13 ± 9.00)%,all P < 0.05],and the levels of LY,LY% and MONO% were increased in acute group [(2.125 3 ± 0.949 9) × 109/L vs (1.794 4 ± 0.606 6) × 109/L,(43.37 ± 14.52)% vs (29.10 ± 7.97)%,(7.84 ± 2.23)% vs (6.55 ± 2.04)%,all P < 0.05].Compared to control group,the level of NEUT% [(54.63 ± 9.26)%] was decreased in chronic group (P < 0.05),and the levels of LY,LY% and EO [(2.212 0 ± 0.633 2) × 109/L,(36.41 ± 8.51)%,(0.153 9 ± 0.028 8) × 109/L] were increased in chronic group (all P < 0.05).The levels of LY% and MONO% [(6.45 ± 1.58)%] in chronic group were lower than those in acute group (all P < 0.05),and the levels of WBC [(6.175 7 ± 1.469 5) × 109/L],EO,EO% [(2.32 ± 1.21)%],BASO [(0.021 8 ± 0.001 9) × 109/L],BASO% [(0.37 ± 0.21)%] and NEUT% were higher than those in acute group (all P < 0.05).The areas under ROC curve (AUCs) of LY and MONO in acute group were 0.681 and 0.529,they were in 0.5-0.7,and the diagnostic value was low;the AUCs of EO,EO%,LY%,NEUT%,NEUT,BASO,BASO%,MONO% and WBC in acute group were 0.816,0.816,0.806,0.790,0.766,0.760, 0.721,0.715 and 0.710,they were in > 0.7-0.9,and the diagnostic value was medium.The AUCs of LY,NEUT,BASO,EO,BASO%,EO%,MONO%,MONO and WBC in chronic group were 0.693,0.617,0.586,0.584,0.581,0.541,0.500,0.513 and 0.510,they were in 0.5-0.7,and the diagnostic value was low;the AUCs of LY% and NEUT% in chronic group were 0.725 and 0.717,they were in > 0.7-0.9,and the diagnostic value was medium.Conclusion The indexes of peripheral WBC in patient with acute and chronic human brucellosis are changed abnormally,which has a certain reference value in diagnosis of human brucellosis.
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Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Endemiology
Ano de publicação:
2017
Tipo de documento:
Article