Heterogeneous t(4;11) fusion transcripts in two infants with acute lymphoblastic leukemia
The Malaysian Journal of Pathology
; : 105-10, 2004.
Article
em Ml
| WPRIM
| ID: wpr-629549
Biblioteca responsável:
WPRO
ABSTRACT
An RT-PCR assay detected the t(4;11) translocation in two infants with acute lymphoblastic leukemia (ALL). Case P76 was a 10-month-old, female infant, who presented with a WBC of 137.4 x 10(9)/l and a pre-pre-B ALL immunophenotype. Case P120 was a 6-month-old female infant, with a WBC > 615 x 10(9)/l and a pre-pre-B ALL immunophenotype. RT-PCR of cDNA from both these cases generated a 656 bp and a 542 bp respectively, which sequencing confirmed as t(4;11) fusion transcripts. The primers and conditions selected for this assay are compatible with a one-step multiplex PCR for the main translocations in childhood ALL.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
Ml
Revista:
The Malaysian Journal of Pathology
Ano de publicação:
2004
Tipo de documento:
Article