A new carotid artery transplantation model of rats / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 131-3, 2009.
Article
em En
| WPRIM
| ID: wpr-635067
Biblioteca responsável:
WPRO
ABSTRACT
To establish a murine carotid artery transplantation model for the study of the chronic rejection, 80 rats were divided into two groups, an allotransplant (ACI-Lewis) group and an isotransplant (Lewis-Lewis) group (control group). The donor carotid artery and the recipient carotid artery were anastomosed by using a polyethylene cuff (internal diameter 0.7 mm, length 3 mm).The pathological changes of carotid artery transplant were observed 14, 28 and 56 days after the transplantation. The results showed that the model was successfully established in 95% of the animals. The chronic rejection-associated arteriosclerosis was induced 28 days after the transplantation. The new chronic rejection model of carotid artery by using cuff technique caused fewer traumas and was easy to make. The pathological changes of the transplant mimicked the chronic rejection-associated arteriosclerosis found in human transplant.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Arteriosclerose
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Ratos Endogâmicos Lew
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Ratos Endogâmicos ACI
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Anastomose Cirúrgica
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Artéria Carótida Primitiva
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Polietileno
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Modelos Animais
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Função Retardada do Enxerto
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Rejeição de Enxerto
Idioma:
En
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Ano de publicação:
2009
Tipo de documento:
Article