Oxidative stress-apoptosis mediated STZ-induced diabetic cataract and the interventions of puerarin / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 1773-1775, 2014.
Article
em Zh
| WPRIM
| ID: wpr-642069
Biblioteca responsável:
WPRO
ABSTRACT
AIM:
To explore the involvement of oxidative stress and apoptosis in the pathogenesis of diabetic cataract induced by Streptozotocin ( STZ) and the interventions of puerarin in order to supply references for clinical treatment.METHODS:
Male SD rats were divided into four groups randomly, control group, diabetic group, apocynin group and puerarin group. The diabetic group were replicated by single injection of STZ (65mg/kg, ip). The expression of p22, p47, p67, Bax/Bcl2, Caspase 3 and P53 proteins were detected by Western Blotting.RESULTS:
The diabetic rats were replicated successfully and the expression of Bcl2 was downregulated while the expression of p22, p47, p67, Bax, Caspase 3 and P53 were upregulated in diabetic group with a significant statistical differences when compared with control group (PCONCLUSION:
NADPH oxidase mediated oxidative stress and P53, Bax/Bcl2 mediated apoptosis are involved in the pathogenesis of diabetic cataract and puerarin can alleviate cataract greatly by inhibiting the aforementioned signal pathway.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
International Eye Science
Ano de publicação:
2014
Tipo de documento:
Article