Effects of Red or Black Ginseng Extract in a Rat Model of Inflammatory Temporomandibular Joint Pain / 치위생과학회지
Journal of Dental Hygiene Science
; (6): 65-72, 2017.
Article
em Ko
| WPRIM
| ID: wpr-649652
Biblioteca responsável:
WPRO
ABSTRACT
Temporomandibular joint (TMJ) pain is characterized by persistent jaw pain associated with dysfunction and tenderness of the temporomandibular muscles and joints. The aim of this study was to investigate whether treatment with red or black ginseng extract helps in the modulation of inflammatory TMJ pain. Male Sprague-Dawley rats weighing 220~260 g were used. The experimental group was subdivided into 4 groups based on the treatment method (n=6, each group): formalin (5%, 30 µl), formalin after distilled water (vehicle), formalin after red or black ginseng extract (per oral, single or repeated, respectively). To induce TMJ pain, 30 µl of formalin was injected into the articular cavity under ether inhalation anesthesia. The number of noxious behavioral responses of scratching the facial region proximal to the injection site was recorded for 9 successive 5-min intervals following formalin injection. Repeated treatment with red or black ginseng extract reduced the nociceptive responses in the second phase (11~45 min). Nuclear factor erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor. Both ginsengs significantly down-regulated the increased Nrf2 level compared to the vehicle group. In the test for liver and kidney functions, repeated treatment with red or black ginseng was not different compared to the vehicle group. These results indicate that red and black ginseng extract might be promising analgesic agents in the treatment of inflammatory TMJ pain.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Articulação Temporomandibular
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Fatores de Transcrição
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Água
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Ratos Sprague-Dawley
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Modelos Animais
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Éter
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Formaldeído
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Panax
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Analgésicos
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Arcada Osseodentária
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
Ko
Revista:
Journal of Dental Hygiene Science
Ano de publicação:
2017
Tipo de documento:
Article