Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds / 药物分析学报
Journal of Pharmaceutical Analysis
; (6): 338-342, 2017.
Article
em Zh
| WPRIM
| ID: wpr-660707
Biblioteca responsável:
WPRO
ABSTRACT
This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Journal of Pharmaceutical Analysis
Ano de publicação:
2017
Tipo de documento:
Article