Add-On Therapy of Quetiapine for Bipolar Disorder: A 6 Month, Prospective Trial / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 279-284, 2005.
Article
em Ko
| WPRIM
| ID: wpr-66436
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES:
This study was conducted to evaluate the overall effectiveness and tolerability of adjunctive quetiapine in the long-term treatment of bipolar disorder as a continuation therapy.METHODS:
Twenty-three bipolar I patients participated and required to have quetiapine add-on treatment in combination with existing or new mood stabilizers. Clinical assessment was carried out using Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI), Hamilton Depression Rating Scale-17 item, Simpson-Angus Rating Scale and Barnes Akathisia Rating Scale at baseline, 1, 4, 12 and 24 weeks.RESULTS:
The YMRS and CGI decreased significantly from baseline to endpoint by 89.7% and 78.3%, respectively (p<0.0001 ; p<0.0001). Twenty-two patients exhibited at least 50% improvement on YMRS score by the end of the study.CONCLUSION:
This study suggests that quetiapine may hold a promise as an adjunct in the long-term treatment of bipolar disorder.Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Agitação Psicomotora
/
Transtorno Bipolar
/
Estudos Prospectivos
/
Depressão
/
Fumarato de Quetiapina
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2005
Tipo de documento:
Article